Hyaluronic acid: biosynthesis and application
نویسندگان
چکیده
منابع مشابه
The biosynthesis of hyaluronic acid by Streptococcus.
The mechanism of hyaluronic acid chain growth in a particulate enzyme preparation obtained from Group A Strepfococcus has been examined and additional characteristics of the enzyme detailed. Hyaluronic acid chain elongation occurs by the transfer of monosaccharide units from uridine nucleoside diphosphate derivatives to the nonreducing ends of endogenous oligosaccharide. This oligosaccharide wh...
متن کاملBiosynthesis of hyaluronic acid by Streptococcus.
Synthesis of hyaluronic acid was investigated in a cell-free system derived from a strain of Group A streptococci. Preparative procedures were improved so that an enzyme system 70 times more active than that previously reported was obtained. The hyaluronic acid synthesized could be separated into trichloroacetic acid-soluble and -insoluble fractions. On the basis of pulse-chase experiments, it ...
متن کاملBiomedical Application of Hyaluronic Acid Nanoparticles
Hyaluronic acid (HA) is a naturally occurring biodegradable polymer with a variety of applications in medicine including tissue engineering, dermatological fillers, and viscosupplementation for osteoarthritis treatment. The cytotoxicity of crosslinking techniques for scaffold fabrication and the high viscosity of viscosupplements have been issues impeding the development of products from HA. Th...
متن کاملThe biosynthesis of hyaluronic acid by group A streptococcus.
Previous publications from this laboratory have reported the use of a strain of group A hemolytic streptococcus for the study of the biosynthesis of the mucopolysaccharide, hyaluronic acid (HA) (1, 2). Methods were devised for the isolation of HA of high purity and the isolation and degradation of fragments of the molecule. Glucose-l-C4 and glucose-6-C4 were used to demonstrate that both the gl...
متن کاملHyaluronic acid and nerve regeneration
The tubulization repair technique is a useful model for studying peripheral nerve regeneration since it provides quantifiable parameters for assessing the effects of exogenously applied substances on nerve repair. In this study, we observed that the local administration of hyaluronic acid (HA) in a tubular prosthesis at the time of implantation significantly improved the repair process, and tha...
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ژورنال
عنوان ژورنال: Ukraïns’kij bìofarmacevtičnij žurnal
سال: 2019
ISSN: 2519-8750,2311-715X
DOI: 10.24959/ubphj.19.212